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Our Location: 19712 MacArthur Blvd, Ste. 100, Irvine, CA 92612
Appointments: (650) 525-4404
Main Fax: (650) 582 – 2895
Working Days: Monday – Friday, 9 AM – 5:30 PM PT
Menopause · Autoimmune Disease · Metabolic Health · Sexual Health

Do you feel exhausted? Achy? Foggy? Gaining weight? and You are told it's stress. You are told it is aging. You are told your labs are normal.
There is another way.Here is what actually happens to most women navigating this stage of life:
Treat hot flashes. Ignore autoimmune disease. Prescribe HRT (Hormone Replacement Therapy) without evaluating clotting risk, disease activity, or immune status — or deny it entirely out of fear, not science.
Manage flares. Ignore hormones. Add immunosuppressants when what you actually needed was a hormone conversation.
Prescribe GLP-1 or cut calories without addressing the real drivers: estrogen loss, insulin resistance, and inflammation. The weight returns because the root cause was never touched.
This is not a knowledge gap.
This is a system that was never designed with you in mind. So what does
a system that was designed for you look like? It starts with one physician who holds all four pieces at
once.
Most practices treat one of these. We integrate all four — because in your body, they are not separate.
Most women are either overtreated with fear or undertreated with silence. There is a precise, evidence-based middle — and most doctors aren't trained to find it. We are.
If your autoimmune disease is flaring and no one has asked about your estrogen levels, you have not had a complete evaluation. Full stop. Rheumatoid arthritis, Sjogren's disease, Hashimoto disease are impacted by hormones, menopause and perimenopause.
GLP-1 works. But in menopausal women, it works incompletely without addressing the hormonal driver underneath. Here's what that means for your results.
Pain with intimacy. Low desire. Changes you stopped mentioning because no one ever asked. These are medical symptoms. They are treatable. And they belong in every evaluation — not as an afterthought.
What exactly happens when all four are addressed together? That's what your evaluation reveals.
REQUEST EVALUATIONNAMS Certified Menopause Practitioner · Board-Certified in Four Disciplines
Telehealth in California · Florida · Oregon
The Menopause Society — NAMS Certified Menopause Practitioner (NCMP)
American Board of Internal Medicine
American Board of Obesity Medicine
American Board of Lifestyle Medicine
Dr. Titianu said "I became a menopause specialist because I was a patient first. I was the doctor who couldn't explain why she felt broken. Fatigue that didn't make sense. Brain fog, I was embarrassed to admit. Joint pain I kept dismissing as stress. I was an internal medicine physician, and nobody had connected my symptoms to my hormones. When I finally understood what was happening to my own body, I was furious. Because I had seen hundreds of women in my clinic with the exact same story. Symptoms that didn't match any diagnosis. Labs that came back 'normal.' Dismissed as anxious. Dismissed as tired. Dismissed as aging.
What they were was hormonal.
So I went back and trained. Lifestyle Medicine. Obesity Medicine.
Menopause Certification through The Menopause Society — the gold standard.
I became what I couldn't find for myself. A doctor who connects autoimmune disease and hormone health in one conversation. In one care plan."


As Seen on NBC — Dr. Titianu has been featured on NBC discussing the intersection of menopause, autoimmune disease, and hormone therapy.
Perimenopause & Menopause
Hormone Replacement Therapy (HRT)
Autoimmune Disease & Hormone Co-Management
Musculoskeletal Syndrome of Menopause
Medical Weight Loss — GLP-1 and metabolic therapies
Sexual & Vaginal Health
Bone Density & Osteoporosis
Cardiometabolic Risk & Menopause
Here is what actually happens to most women navigating this stage of life:
"Finding Dr. Titianu has been a life-changing experience. Navigating perimenopause with autoimmune disease was overwhelming — she gave me clarity I had searched years for."
— Sarah M. Perimenopause + Rheumatoid Arthritis"Dr. Titianu is a great physician — compassionate, a great listener, and up to date with the newest guidelines. I spent three years being told my labs were normal. One visit changed everything."
— Linda R. Menopause + Hashimoto's"The weight I couldn't lose for four years started coming off once my hormones were properly addressed. She listens. She investigates. She fixes the actual problem."
— Diane T. Perimenopause + Metabolic Weight Gain"Finally a doctor who understands that my joint pain and my menopause symptoms are connected. I feel seen for the first time in years. The structured program makes a real difference."
— Jennifer A. Sjögren's + PerimenopauseThree stages that build on each other. You are not starting over at every appointment — you are progressing toward measurable stability. Telehealth from the comfort of your home.
"Sexual Health is part of Your Health. Pain with intimacy. Low desire. Dryness. Changes you've stopped mentioning because no one ever asked. These are treatable. Not inevitable. And they belong in your care. Hormones change everything — including this. We address it at every visit." — Dr. Mirela Titianu, MD
"Menopausal weight gain is not a willpower problem. It is a hormone problem. GLP-1 works—but not without addressing the estrogen decline that drives the resistance in the first place. We prescribe it the right way: after a full hormonal, metabolic, and autoimmune evaluation." — Dr. Mirela Titianu, MD, Board-Certified Obesity Medicine
If your autoimmune diagnosis is unclear, seronegative, or you need expert risk stratification before HRT (Hormone Replacement Therapy), Dr. Girnita provides a dedicated rheumatology-level evaluation before your program begins.

No waiting rooms. No travel. No time off work. Full physician-led telehealth visits — same standard of care, delivered where you are most comfortable.


Traditional clinics optimize for speed and billing codes. We optimize for outcomes.
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